Half human, half-vampire, Agent Blood Rayne has superhuman strength, agility and senses that make her capable of skills far beyond the scope of a normal human. This formidable huntress works for the Brimstone Society–an underground organisation that seeks out and destroys supernatural threats. Two missions, five years apart, turn out to be connected by one man: Jurgen Wulf. For years, he´s been searching for powerful occult artefacts that would bring Nazi Germany into a new age of domination during WWII. Blood Rayne is the world´s only chance to defeat his elite Nazi army and prevent them from releasing untold horror upon its people.